Founding CEOs are a fundamentally different animal from non-founding CEOs, in companies of all sizes from 10 to 10,000.
Founders are a breed with wildly varying business skills, but with the charisma, vision, and bravado to decide to start a company.
Non-founders may be seasoned executives who are incredibly skilled at running companies (like those prototypical CEOs you see on TV and at the helms of large traditional businesses), but very well might not have the stomach or the skills to found a company.
Non-founders better well respect what it takes to found a company. And for the most part, founders should keep starting businesses and embrace that they don't ever want to be those corner-office, as-seen-on-TV type executives.